Devonbosch Pharmacy

Non-Sterile Compounding

Non-sterile compounding is a service provided by Devonbosch Pharmacy. It involves the
preparation of customised medications that do not require aseptic or sterile environments, as
these products are administered through routes such as oral, topical, rectal, or vaginal
administration rather than injection or intravenous infusion.

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Devonbosch Pharmacy

Why Non-Sterile Compounding
is Essential

According to pharmaceutical compounding standards, non-sterile compounding includes the combining, mixing, diluting, or altering of pharmaceutical ingredients to create personalised medications tailored to specific patient needs.

These services are commonly used when commercially available medications do not meet a patient’s clinical requirements, such as when specific doses, dosage forms, allergens, or excipients must be modified.

Devonbosch Pharmacy

Types of Non-Sterile Compounding Products

Devonbosch Pharmacy can prepare a wide variety of customised non-sterile dosage forms. Typical examples include:

Oral Preparations

Non-sterile compounding frequently involves the preparation of oral medications designed to provide personalised dosing or improve patient compliance. These include:

  • Capsules
  • Tablets
  • Oral solutions
  • Oral suspensions
  • Syrups
  • Flavoured paediatric liquids
  • Sublingual drops or troches
  • Nasal Sprays
These formulations are often used when patients require different strengths, alternative dosage forms, or improved palatability.

Topical and Transdermal Preparations

Devonbosch Pharmacy can produce customised topical medications that are applied to the skin for localised or systemic therapeutic effects.

Examples include:

  • Dermatological creams
  • Ointments
  • Gels
  • Transdermal creams
  • Lotions
  • Medicated shampoos
  • Lip balms
These products are frequently used in the treatment of dermatological conditions, pain management, wound care, and hormone replacement therapy.

Suppositories and Vaginal Preparations

Devonbosch Pharmacy may also prepare medications intended for rectal or vaginal administration.

Examples include:

  • Rectal suppositories
  • Vaginal suppositories
  • Hormonal suppositories
  • Anti-infective vaginal preparations
These formulations are used when oral or topical administration is unsuitable or when localised therapy is required.

Customised Hormone Therapy Preparations

Non-sterile compounding provides individualised hormone formulations such as:

  • Progesterone capsules or creams
  • Oestradiol and estriol preparations
  • Testosterone creams or gels
  • DHEA formulations
These therapies are frequently used in personalised hormone replacement therapy programs under medical supervision.

Devonbosch Pharmacy

Customisation Services in Non-Sterile Compounding

In addition to producing various dosage forms, Devonbosch Pharmacy provide customisation services such as:

  • Adjusting medication strength or dosage
  • Removing allergens (e.g., lactose, gluten, dyes, preservatives)
  • Producing sugar-free or alcohol-free formulations
  • Combining multiple medications into a single dosage form
  • Flavouring medications for paediatric or veterinary patients


These services enable Medical Professionals to create medications tailored to individual patient needs when commercial products are unsuitable.

Devonbosch Pharmacy

Quality Assurance and
Regulatory Oversight

Sterile compounding is supported by comprehensive quality assurance systems
including routine air and surface monitoring, cleaning and disinfection schedules, equipment validation and
maintenance, documentation and batch traceability, and internal audits and continuous improvement processes.

Aseptic manufacturing in South Africa is regulated under the Pharmacy Act, Good Pharmacy
Practice (GPP) standards, and oversight by the South African Pharmacy Council (SAPC).
Compounding pharmacies are subject to inspection and must demonstrate compliance with
facility, process, and professional requirements.

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